La tilidina viene assorbita rapidamente dopo la somministrazione orale ed è soggetta a un pronunciato effetto di primo passaggio. La conversione della tilidina nel metabolita più attivo nortilidina avviene con il coinvolgimento del CYP3A4 e CYP2C19. L'inibizione di questi enzimi può quindi alterare il profilo di efficacia e tollerabilità della tilidina.
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If you really feel the impact of the medicine is just too weak or much too powerful, usually do not change the dose by yourself, but check with your doctor.
انتقل إلى المحتوى القائمة الرئيسية القائمة الرئيسية
Nuspojave u gastrointestinalnom traktu (zatvor i mučnina) kao i oslabljeno disanje (respiratorni depresivni učinak) rjeđe se primjećuju kada se analgetik daje u uobičajenoj kombinaciji s naloksonom. Kao daljnji nepoželjni učinak često se primjećuje pojačano znojenje.
It's recommended to Restrict the level of grapefruit juice you drink even though using Tildiem as it could possibly raise the blood levels of the Lively ingredient diltiazem and could increase your prospect of finding side effects. For anyone who is worried you need to prevent consuming grapefruit juice and consult your physician.
الامر المهم الاخر هو ما اذا كان المريض قد تناول الطعام خلال الفترة السابقة
السيلدينافيل ، تادليفيل ، و الفاردينافيل تزيد من تأثير ديليتيلزيم الخافض لضغط الدم ( يستخدم بحذر). مستوى و تأثير ديليتيازيم قد يقل عند استخدام : أمينوغلوتاثيميد ، كاربامازيبين، نافثسيلسن ، نيفاربين ، فينوباربيتال ، فينيتوين ، ريفاميسين. عملية الايض للديلتيازم تحدث في الكبد لذا فقد يؤثر على غيره من الادويه التي تحدث لها عملية الايض في الكبد .
حمل تطبيق الطبي للحصول على أفضل الاستشارات الطبية خلال دقائق وبخصوصية تامة
Tilidine Tilidine is used in the shape of hydrochloride or phosphate salt. In Germany, tilidine is out there in a hard and fast mix with naloxone for oral administration (Valoron N and generics); the combination of naloxone is claimed to decreased the abuse legal responsibility on the opioid analgesic.[3] This is often so that if people take the medication orally (that's just how they are supposed to) the opioid blocker, naloxone, has minimal effects on them but whenever they inject it the naloxone gets bioavailable and consequently antagonises the effects tilidin höchstdosis in the tilidine developing withdrawal effects.
Inform your medical professional or pharmacist If you're taking, have not too long ago taken or may well just take some other medicines.
Leider rutscht mein Gleitwirbel trotz Krankengymnastik nicht wieder zurück… ich nehme jetzt aber morgens uns abends nur noch eine halbe Tablette und komme damit (speedy) Schmerzfrei über die Runden…
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I contenuti presentati non sostituiscono il foglietto illustrativo originale del medicinale, in particolare for every quanto riguarda il dosaggio e gli effetti dei singoli prodotti.